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( G ) Relative protein expression of TCF7L2 in HG, HG + emodin and HG + emodin + TCF7L2 SiRNA groups
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15,23 GSH depletion in the brain is a common finding in patients with neurodegenerative conditions eg Alzheimers disease and Parkinsons disease, which can cause neurodegeneration prior to disease onset
118 Redox reactions at key cysteine residuesnamely, s -glutathionylation at Cys346 119 and reduction of the Cys272-X-X-Cys275 disulphidealso enhance CBS enzymatic activity
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