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The relatively high percentage of Ki67 positive cells that represent cells in an active cell cycle, as compared to BrdU positive cells that represent any proliferation over the 7 days, implies that maximal replication likely occurs at 7 days (time of analysis)

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Journal of gastrointestinal and liver diseases : JGLD

If you titrate past that dose within the first three months, you will need to switch to the pricier monthly plan