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It was originally isolated from human plasma in 1973 and has since become one of the most widely researched copper peptides in published scientific literature

Sulfadimethoxine was used as the lock mass (m/z 311.0814+) for accurate mass calibration in real time

J Organomet Chem 1016:123260 AshwlayanVD KA, Verma M (2018) Therapeutic potential of Calendula officinalis

Although the functions of granins are still being elucidated, secretoneurin has been shown to induce mucus hypersecretion in human airway epithelial cell lines (16HBE and NCI-H292) and induce expression of muc5AC [36], suggesting a modulatory role in mucus secretion