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Although these findings do not completely exclude the effect on kidney parenchymal cells or off-target effects, these results suggest that sulfasalazine prevents the formation of TLS not by attenuating tubular injury but via its inhibitory effect on of the cystine/glutamate transporter specifically expressed within TLS

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Generally, Cu2+ is converted to Cu+ by reductase enzymes such as duodenal cytochrome b (DCYTB) and six-layer epithelial antigen (Fig

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, 116 , 2283-2292, doi: Guo, W., Zhao, Y., Zhang, Z., Tan, N., Zhao, F., Ge, C., Liang, L., Jia, D., Chen, T., Yao, M., Li, J., and He, X