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These comprise both hepatic and extrahepatic conditions, including portal hypertension in cystic fibrosis, porto-sinusoidal vascular disease, malignant mesothelioma, incident type 2 diabetes (T2D), cardiovascular disease risk, metabolic syndrome, fibrosing NAFLD, chronic kidney disease (CKD), neurodegenerative disorders and dementia, idiopathic pulmonary arterial hypertension, and Corona Virus Disease 2019 (COVID-19)

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Science, 380 , eabn9257

The bioregulator hypothesis No receptor for AEDG has been identified