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Efectos a largo plazo y efecto rebote al dejarlo Sobre los efectos a largo plazo , la evidencia disponible muestra un perfil de seguridad razonable bajo supervisin mdica, siendo los efectos digestivos los ms persistentes (1)

Patients with diabetes taking semaglutide should be particularly vigilant, as they may experience atypical or less pronounced symptoms due to diabetic neuropathy affecting sensory perception

Emerging clinical reports suggest that GLP-1 agonists may induce reductions in lean mass, including skeletal muscle, potentially compromising exercise capacity independently of central effects (Karakasis et al., 2025

These issues are increasingly relevant to health-system implementation, as contemporary guidance is integrating OMMs into chronic obesity care pathways while still constraining access according to BMI, comorbidity and early treatment response

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