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In patients with type 2 diabetes, treatment with semaglutide 1 mg resulted in reductions in glucose in terms of absolute change from baseline and relative reduction compared to placebo of 29 mg/dL (22%) for fasting glucose, 74 mg/dL (36%) for 2-hour postprandial glucose, and 30 mg/dL (22%) for mean 24-hour glucose concentration (see Figure 1)

Tolerability and Preliminary Safety Data Short-Term Tolerability: Scientific opinion seems to lean toward "safe" rather than "unsafe" based on initial, limited data

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GLP-1 receptor agonists like Wegovy, Saxenda and Zepbound will be restricted in Michigan "exclusively to individuals classified as morbidly obese" under the new budget, with coverage contingent on the failure of other weight loss interventions to prevent higher-cost bariatric surgery