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Curli protein binds to and activates TLR2, leading to an increase in intracellular -syn, which in turn triggers a neuroinflammatory response through the TLR2/MyD88/NF-B pathway (18, 19)
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Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
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When ROS production exceeds the protective capacity of HSPs, oxidative stress may further aggravate proteostatic disruption and apoptosis, thereby amplifying heat stress-induced reproductive damage
