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The research protocol was performed with the approval of the Ethics Committee of Harbin Institute of Technology (Approval No: HIT-2022008)

Interestingly, in this study aimed at assessing the mechanistic role of IGF-1R signaling in the regulation of organ-specific metastasis of platinum-taxol-resistant A2780 EOC cells in orthotopic xenograft mouse models, IGF-1R silencing abrogated organ-specific metastasis of EOC cells augmented by acquired chemoresistance, and enhanced lung homing of the late-stage chemoresistant cells

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doi:10.3389/fphar.2014.00173

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Metabolic rate increases occur through multiple mechanisms including brown adipose tissue activation