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10.1016/j.ecoenv.2020.111829 8 AkayA.KoleliN

This impairs Notch2 degradation and sustains oncogenic Notch2 signaling, which upregulates c-Myc and Cyclin D3 expression

& Boulias, C

doi: 10.1038/nature11450 101 RauM.RehmanA.DittrichM.GroenA

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Serum LH level is also significantly reduced to below the lower limit of the normal range, probably due to the negative feedback mechanism or compression of the normal pituitary gland by the tumor [4, 5, 7]