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Compounds outside that system have not cleared the safety and efficacy bar that approved drugs have
Lixisenatide and liraglutide have half-lives of 2.6 h and 12.614.3 h, respectively and are taken once daily
Whether they ever will depends less on the receptor, whose biology is no longer in serious doubt, than on two engineering problems that the recent failures have brought into focus: getting the compound to the right neurons, and getting the right patients into the trial
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