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The Bottom Line The Alzheimer's Association has launched the largest dementia prevention trial in history $100 million, global enrollment, testing whether GLP-1 drugs combined with a proven lifestyle intervention can prevent cognitive decline before it begins

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7.4 Catestatin and autonomicmetabolic regulation Catestatin, a peptide derived from the prohormone chromogranin A, inhibits catecholamine release and modulates sympathetic tone

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The lip corners also trap moisture from saliva, which macerates the skin and weakens its barrier function, compounding the inflammatory cycle

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat