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It was first characterized as an incretin hormone, meaning it enhances glucose-stimulated insulin secretion from the pancreatic beta cells

During AOD 9604 and tirzepatide combination therapy, resistance training becomes even more important because the aggressive fat loss rate means the body will readily catabolize muscle if it is not receiving the stimulus to maintain it

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Ng, J Sun et.al, Metabolic Studies of a Synthetic Lipolytic Domain (AOD 9604) of Human Growth Hormone, Hormone Research, February 2000

Folic acid has also been shown to decrease vitamin B12 levels as well