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Studies have shown that in early PD patients with a disease duration of less than 4 years, iron accumulation in the SNpc occurs 4.19.6 years prior to the clinical diagnosis of PD and precedes SNpc neuromelanin (NM) lossa marker of dopaminergic neuronal degenerationby 2.63.7 years

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Frontiers in Nutrition, 7

Bibcode:1964Natur.203.1068H

Focus has since expanded to include tendon and ligament repair, muscle recovery, neurological function, and vascular health

That slow decline is the reason a once-weekly schedule keeps levels fairly steady between injections