It was originally isolated in 1977 from the cerebral venous blood of rabbits and has since been found to be present in small amounts in human brains and plasma, with higher concentrations later in the day.3 4 It, or a similar substance, is also present at higher concentrations in human breast milk.5 Because DSIP can cross the blood-brain barrier and is easily absorbed via the gut (unusual for a peptide), some researchers have hypothesized that it may facilitate post-feeding sleep tendencies among newborns, though it remains unclear whether DSIP truly has a hand in neonate sleep-wake cycles.4 5 6 Its mechanism of action is likewise unclear, but it may have something to do with endocrine regulation
Pediatrics Safety has not been established GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine (G), histidine (H), and lysine (K)
DO THIS INSTEAD: You can increase natural-growth-hormone production by fasting, getting a good nights sleep (growth-hormone levels are highest when you sleep), working out (high-intensity exercise seems to work best), losing excess body fat, and limiting sugar and other refined carbs
Cancer Cell 15 , 220231 (2009)
Blevins JE, Honeycutt MK, Slattery JD et al (2024) The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-dependent manner
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