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The activation of these receptors in the hippocampus, a region crucial for memory formation, is believed to enhance synaptic plasticity and neurogenesis, providing a direct biological basis for the cognitive-enhancing effects observed in preclinical studies (During et al., 2003)
Neurochem Res 23:108591, PMID: 9704598 Gilbert KR, Aizenman E, Reynolds IJ (1991) Oxidized glutathione modulates N -methyl-d-aspartate- and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neurons
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Continuous nightly use is supported, over the studied window, by the trial record showing maintained GH output without desensitization
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