L-cells are a type of enteroendocrine cells (EECs) that are found in different parts of the digestive tract and produce hormones that regulate various digestive and metabolic processes in the body
Mechanism plausible from animal data
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PT-141 acts specifically on the excitatory arm of this system via melanocortinergic activation, providing the mechanistic rationale for its research application in models of central sexual desire dysregulation
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In summary, our data implicate a novel mechanism protecting against liver steatosis via an oxidative stress adaptive response that activates the AMPK pathway