Common side effects may include: Nausea or upset stomach Changes in bowel habits (constipation or diarrhea) Mild fatigue Heartburn To manage these, providers often recommend eating smaller, more frequent meals and staying hydrated
STEP-8 compared semaglutide 2.4 mg once weekly head-to-head against liraglutide 3 mg once daily in 338 adults with obesity
BMI of 30+ without conditions
Why You Feel Tired on Ozempic or Mounjaro (GLP-1 Fatigue Explained) Last updated: March 2026 Understanding fatigue on GLP-1 medications like Ozempic, Wegovy, Zepbound and Mounjaro whats normal, whats not, and what to consider
The cost of GLP-1 medications, such as Ozempic and Wegovy, has been a primary driver of increased healthcare spending in the state
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