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[36] [39] In animals and plants, the first two steps of the saccharopine pathway are catalysed by the bifunctional enzyme, -aminoadipic semialdehyde synthase (AASS), which possess both lysine-ketoglutarate reductase (LKR) (E.C 1.5.1.8) and SDH activities, whereas in other organisms, such as bacteria and fungi, both of these enzymes are encoded by separate genes

doi: 10.1016/0014-5793(87)81430-8 24 MojsovSWeirGCHabenerJF

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Furthermore, a pragmatic, randomized, controlled clinical study was conducted with 230 PCOS women, randomly assigned to the NAC group (1.8 g/day oral NAC, n = 115) or the control group ( n = 115)