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Clinical guidance from NHS Lothian suggests that if you are on oral progesterone and starting a GLP-1 medication, it may be logical to increase the dose from 100 mg daily to 200 mg daily for the first 4 weeks of GLP-1 treatment, after which the gastroparesis risk typically diminishes at a stable dose

This is why some people feel like "nothing is happening." The scale is not moving, so they assume the peptide failed

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Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

[33] broadened the scope to 26 studies ( n = 3,020), including both metabolic RCTs with secondary psychiatric outcomes and a small number of trials in clinical populations (e.g., substance use disorders)