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Description

This leads to reduced calorie intake, which is key to weight loss

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FGF15 controls bile acid synthesis and hepatic lipid metabolism, impacting gluconeogenesis by inhibiting the CREB-PGC-1 pathway

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The receptor employs a two-domain binding mechanism where the extracellular domain (ECD) captures peptide C-termini as an affinity trap while the N-terminal peptide segments insert into the transmembrane domain (TMD) orthosteric pocket to trigger activation

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