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Infiltration by monocytes of the CNS and its role in multiple sclerosis: reflections on therapeutic strategies

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Although current research indicates that ferroptosis plays a central regulatory role in the pathological process of FRDAlinking mitochondrial iron accumulation, neurodegeneration, and cardiomyopathyand provides a new theoretical anchor for understanding the FXN deficiencyiron dysregulationtarget-organ injury axis, several fundamental limitations remain

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While early evidence highlights diverse potential roles, mechanisms remain incompletely defined, and outcomes vary with context and model system

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