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Those with naturally high NNMT activity might respond more dramatically to inhibition, while those with lower baseline activity might see more modest effects
4 : 0.3), excellent microsomal stability, negligible CYP inhibition, and minimal P-gp efflux, yielding robust CNS penetration (Chino et al., 2018)
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Twice-weekly dosing may actually be less safe due to increased injection-site reactions and higher risk of dosing errors
(2019) 60:M184m203
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