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Furthermore, the clinical heterogeneity of PD, along with the absence of definitive diagnostic biomarkers in early stages, complicates patient stratification and endpoint definition in trials (see details in [15])
Yet, in many countries the devices being used to deliver GLP-1s are the same for both the weight loss and T2D populations and, in many cases, were originally designed for delivering insulin, such as Novo Nordisks FlexTouch pen (Wegovy, semaglutide) or Eli Lillys KwikPen (Mounjaro, tirzepatide) outside the US
doi: 10.1016/j.cell.2007.03.015 102 JiXHJiJZZhangHLiBM
The abdomen also tends to have less nerve density than the thigh at the specific insertion points used, which translates to less sensation during injection
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