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Strength training and enough protein protect lean muscle mass, according to the American Diabetes Association, and losing that muscle (sometimes called sarcopenia) is a real risk with GLP-1 medications

With that proof of concept in hand, we then investigated the possibility of combining the peptide/oligourea hybrid approach with the protraction strategy, which consists of functionalizing a peptide with a fatty acid chain to promote its binding to albumin and prolong its in vivo half-life

This gradual approach reduces nausea and gastrointestinal side effects that occur when patients start at higher amounts

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doi: 10.1111/j.1532-5415.2005.53250.x 28 DashSAydinYWidmerKENayakL