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In the future, longitudinal studies will be necessary to capture trajectories of changes over time in AC levels and depressive symptoms in order to properly disentangle trait vs state effects and provide empirical grounding for causal interpretation, triangulating evidence with experimental medicine approaches

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Cieslik KA, Sekhar RV, Granillo A, Reddy A, Medrano G, Heredia CP, et al

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While disconcerting, this pattern typically resolves as the nervous system adapts to retatrutide