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A 12-week study in which patients diagnosed with T2DM were treated with the DPPIV inhibitor, sitagliptin, revealed increased serum levels of PYY 1-36 and improvement of glucose and non-glucose dependent insulin secretion 71

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El GLP-1 es degradado de forma rpida en la circulacin por parte de la DPP-4, la cual escinde residuos de alanina o prolina ubicados en la penltima posicin del extremo N-terminal, lo que explica su vida media corta (1-2 minutos) 15 , pero que permite que a niveles fisiolgicos se cumpla su efecto incretina en la CBP 18

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