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A comprehensive analysis of the known effects of GLP-1 and GLP-1RAs on cognitive, cellular, and molecular changes in NDD in preclinical and clinical studies have shown that both natural GLP-1 and its analogues, GLP-1RAs (dulaglutide, exenatide, liraglutide, lixisenatide, semaglutide, and tirzepatide) improve cognitive and motor functions
Suryadevara, V
doi:10.1016/S0022-3565(25)05394-7
acetylcholine Brain Optimization
Representative of n = 3 independent experiments with similar results
Furthermore, MD revealed decreased flexibility of p53 TAD2 in complex with FOXO4-DRI compared to the FOXO4 FH -bound state with RMSDs of 1 heteronuclear NOE data was recorded using the HSQCNOEF3GPSI bruker pulse sequence (32 scans, 256 points in F1, 1024 points in F2, 1278.772 Hz spectral width in F1, 9615.385 Hz spectral width in F2) using a three seconds saturation period
