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7 In these emergency situations, a single low dose of rasburicase (0.02 to 0.05mg/kg up to 3mg) can be administered and it is recommended that hemodialysis be readily available in the event of clinically significant hemolysis and acute renal failure

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Furthermore, Nrf2 activators reduce the extent of neuronal death caused by iron overload, most likely by regulating genes associated with iron metabolism and the synthesis of antioxidants that protect cells from oxidative stress and ferroptosis [48, 49]

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