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At the same time, copper itself is a required cofactor for several angiogenic enzymes and transcriptional programs, and the GHK peptide appears to deliver copper in a biologically functional form at sites of cellular injury
Preclinical Research Dosing Models Animal model studies have explored GHK-Cu at the following ranges: Topical (in vitro/ex vivo): 10100 M concentrations in cell culture media Subcutaneous (rodent models): 15 mg/kg body weight, administered 12x daily Wound healing models: Local application at 110 g/wound site Reconstitution for Research GHK-Cu is typically supplied as a lyophilized powder
use of supplements containing glutathione and/or other antioxidants within one month prior to the study
(2003) published comprehensive reviews documenting BPC-157's effects in various GI models, observing that the peptide demonstrated notable activity in multiple experimental paradigms