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If a selective amylin agonist can hold roughly 20% at the top dose while producing placebo-like adverse-event rates at lower doses, the interesting downstream question becomes combination and sequencing, not replacement
The table gives Contrave an onset of 4 to 8 weeks with minimal nausea but possible stimulant side effects, against 2 to 4 weeks for GLP-1 agonists with common early nausea and vomiting that improves over time
Prescribers can write off-label prescriptions for weight management, but if thats your primary goal, the Wegovy pill is probably the better fit
A comprehensive approach including glycemic optimization, lifestyle modifications, cardiovascular risk management, and specific ED therapies offers the best outcomes
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