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Reduced appetite: GLP-1 medications can result in a lack of interest in food, potentially leading to undereating, causing nutrient deficiencies and potential muscle loss

No formal withdrawal syndrome, but you may experience rebound symptoms : increased appetite, digestive changes, mood swings, and blood sugar fluctuations

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Off / washout (after the block): A typical research framing runs a defined block (commonly 812 weeks) followed by an off period before any subsequent block, rather than indefinite continuous use because long-term human data simply do not exist

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