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545 For example, pelacarsen, an Lp(a) ASO drug developed by Ionis in collaboration with Novartis AG, effectively lowers Lp(a) levels by selectively cleaving Apo(a) gene (LPA) mRNA
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In PD, post-mortem studies consistently reveal a selective decrease in GSH levels in the substantia nigra, a change that precedes overt neurodegeneration and correlates with disease severity
It works by promoting synaptic growth and strengthening brain signaling pathways, which may help with information recall, concentration, and overall cognitive performance
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For example, with NAD+, despite little evidence of benefit in humans, there are laboratory research findings that it has a role in cancer
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