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111 Lifestyle management is integral throughout MASLD, with some perspectives advocating for initiation as long as metabolic risk factors are present
Feng, X., Zhang, L., Xu, S
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Although those benefits have been demonstrated only for specific OMMs (that is, tirzepatide for OSAS and semaglutide for KOA), it is plausible that these effects are largely driven by weight reduction rather than by unique pharmacodynamic properties of each molecule 55,56
It is important to note that animal models for later stages such as hepatic fibrosis and cirrhosis are often induced pharmacologically rather than through alcohol exposure
This reflects earlier findings among people with type 2 diabetes who lost weight after intensive lifestyle interventions: those who lost more weight still had improved hemoglobin A1c levels (a measure of blood sugar) after four years, even after regaining all the weight
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