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Historically important, it remains used in nutritional research for its ability to strongly stimulate appetite , making it a tool for studying hypothalamic regulation of food intake
University of Pennsylvania
Even then, serum testing reflects recent circulating levels not tissue-stored body burden, which may be significant even when blood levels have normalised
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introducing additional immune-active compounds without full diagnostic workup adds unpredictable variables
Binding triggers Gs-coupled adenylyl cyclase activation, raising intracellular cAMP and downstream protein kinase A (PKA) signalling in each target tissue
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