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Recent evidence supports the use of GLP-1 RAs in patients with obesity-related HFpEF

Patients with certain GLP1R variants, for example, may benefit from dose escalation earlier, while others with GIPR sensitivity may gain more from tirzepatide's dual-receptor activity

As noted in the study, semaglutide interacts with many diabetes drugs and medications that impact blood sugar

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Methods PubMed, Cochrane, Web of Science and Embase were searched for randomized placebo-controlled trials with SGLT-2i or GLP-1 RAs as interventions of type 2 diabetes patients up to June, 2024