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Glucagon-like peptide-1 (GLP-1) receptor agonists were first developed in the 1990s to treat type 2 diabetes by stimulating insulin secretion in response to glucose

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The LEADER trial of liraglutide, conducted on 9340 patients, was the first trial in which a GLP1RA was used to document an improvement in MACE in patients with T2D and established ASCVD [4]