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42 HSYA reduced LDH levels in coronary effluents, prevented ischemia-induced cardiomyocyte apoptosis and mitochondrial membrane depolarization, increased phosphorylation of endothelial nitric oxide synthase (eNOS), and inhibited Ca 2+ -induced mitochondrial swelling and opening of the mitochondrial permeability transition pore, providing substantial protection in MIRI rats

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Results Totals of 13/30 (43%) and 7/17 (41%) statements achieved consensus in Rounds 1 and 2, respectively

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Pigment storage is a consequence of colonic epithelial cells apoptosis, in which the apoptotic cells are swallowed by macrophages, which migrate in the lamina propria and the conversion into lipofuscin pigment occurs by lysosomal enzymes (19)