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The immunological barrier comprises secreted IgA, which is produced in plasma cells in the lamina propria, and a full complement of immune cells located in the lamina propria and gut-associated lymphoid tissues ( The role of the intestine in metabolic homeostasis has been mainly ascribed to enteroendocrine cells, that act as sensors for nutritional signals and produce and secrete key hormones, such as glucose-dependent insulinotropic polypeptide (GIP), glucacon-like peptide 1 (GLP-1) and peptide YY, into the circulation ( in vivo , such as anti-hyperglycemic effects ( via increased GLP-1 secretion from L cells and enhanced neural signaling ( 3 The Intestinal Immunological Barrier in Obesity and T2D 3.1 Modulation of LPS and Metabolic Endotoxemia As a membrane component of gram-negative bacteria, LPS is found in copious quantities in the gut as part of commensal microbiota and pathogens

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Neuropsychopharmacol Reports 40:291296

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