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Riboflavin-5-Phosphate (Active Vitamin B2) Supports mitochondrial energy production, antioxidant pathways, and nervous system function
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277,278 Complementing these cellintrinsic models, Farrell extended network adaptation to the tumor microenvironment, arguing that resistance is ecologically driven by crosstalk among cancer cells, CAFs, and macrophages via paracrine signals and exosomes, enabling noncellautonomous drug tolerance
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