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The area under the curve of human GLP-1 and GLP-1RAs reacted with excess DPP-4 under the same conditions was taken as a representation of their hypoglycemic effect and duration in vivo
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HIF-1 overexpression or HO-1 agonist treatment suppresses TECs apoptosis by preventing hyperglycemia-induced mitochondrial membrane potential loss and mitochondrial fragmentation to eliminate tubular injury in DKD (108)
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