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We now have randomized controlled trial data from 2024 and a prospective substudy from 2025 documenting measurable changes in both

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Founder animals carrying alleles with small deletions were backcrossed to wild type animals (strain C57BL/6J) for 12 generations to outbreed affected off-targets and then bred to homozygosity

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Benefits of GLP-1 and related therapies When prescribed and monitored by a doctor, these medicines may help patients achieve: Significant weight loss Improved blood-sugar control Reduced cardiovascular risk Lower blood pressure in some patients Improved metabolic health GLP-1 receptor agonists are already widely used for type 2 diabetes and weight management, and ongoing research suggests they may have benefits beyond these conditions