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While the breadth and consistency of these findings across multiple large-scale, peer-reviewed publications is scientifically encouraging, definitive confirmation of a cancer-preventive effect will require prospective, randomised controlled trials with long-term follow-up and systematically adjudicated cancer endpoints

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The normal LH group did not show a response at either timepoint, suggesting a different neurochemical cause for their hypothalamic amenorrhea

Yet, some procarcinogens require phase I enzymes in order to become active carcinogens capable of binding DNA and forming cancer-causing DNA adducts

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On the basis of a range of biochemical and thermodynamic arguments, Williams (1982) suggested that the oxidation state of cytosolic iron is iron(II) and that its concentration falls in the range 10 7 10 6 M, a proposal supported by fluorescence studies (Breuer et al 1995)