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In a Phase I study with recombinant human thymosin beta-4, the terminal half-life was about 0.5 to 2.08 hours, for example 1.02 hours at 0.5 microg/kg and up to 2.08 hours at 25 microg/kg, with linear, non-accumulating kinetics and dose-proportional Cmax Wang et al., 2021

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Glachant S, Salle B, Langlois-Jacques C, et al

We call a stroke in the optic nerve nonarteritic anterior ischemic optic neuropathy (NAION)

Also in livestock (boars), retarded sexual development was shown with Se excess in feed, with a gradual decline in sperm production (85, 169)