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We treated human TC cells (K1, MDA-T68, MDA-T32, TPC1) with (1S,3R)-RSL3 (RSL3), a small-molecule inhibitor of GPX4 and examined the effects on ferroptosis, tumor cell survival and migration, spheroid formation, oxidative stress, DNA damage repair response, and mTOR signaling pathway in vitro
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Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing [PMID: 17937621] Laboratory literature summary: Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents
Its a maths-only value for planning notes
It exists because long-term human safety data does not exist for either compound
Im curious if you factored in specific pre-analytical confounders over this 10-day window
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