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Before beginning any supplementation regimen, particularly if you have existing health conditions or take medications, consulting with a healthcare provider is always recommended to ensure safety and appropriateness for your individual situation.

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If you are not drinking enough water, your body has to work much harder to perform basic cellular functions, resulting in pronounced tiredness

For instance, atrasentan, an ERA, reduced kidney outcome risk by 35% but was also associated with a non-significant increase in hospitalization for HF [16]

In addition to these general metabolic changes linking impaired energy production to fatigue as a common symptom between long COVID, ME/CFS and MDD, common differences in specific metabolites may also be of importance