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Still, when it was noted that the drug helped to manage body weight, it was also studied and approved as a weight-loss treatment
(PubMed) American Academy of Pediatrics, Committee on Nutrition
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doi:10.1074/jbc.M209264200 43
In the 28-week, phase three randomized control trial (RCT) DURATION-8, dual therapy with an SGLT2 inhibitor (dapagliflozin) and a GLP-1RA (once-weekly exenatide) was shown to reduce HbA1c by 0.4% more than either agent alone, in patients with a starting HbA1c of between 8-12% 50 , illustrating that the glycemic response to dual therapy is less than additive 50
Its important to remember that weight loss takes time and requires a comprehensive approach to maintaining a healthy lifestyle
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