Consider Alternatives If Who Should Avoid Do not use if You have active cancer or a history of cancerIGF-1 can stimulate cell growth including potentially cancerous cells You are pregnant or breastfeedingeffects on fetal/infant development are unknown You have diabetic retinopathyIGF-1 may accelerate eye blood vessel growth You have uncontrolled diabetesblood sugar management becomes extremely difficult You are under 21can affect natural growth plate closure and hormonal development You've had allergic reactions to IGF-1 or similar peptides Use with caution if !You have any insulin resistance or pre-diabetesmonitor blood sugar very carefully !You take medications that affect blood sugar levelsinteractions can be dangerous !You have heart conditionsIGF-1 can cause cardiac tissue growth !You have kidney or liver issuesmay affect peptide metabolism !You have carpal tunnel syndromeIGF-1 can worsen symptoms !You have a family history of cancerdiscuss with your doctor first Administration How do I use it
Clinicians should consider GLP-1 therapy when lifestyle modificationsincluding dietary changes and increased physical activityhave proven insufficient to achieve weight loss goals
All peptide therapy programs are based on provider evaluation, medical history, patient goals, and clinical appropriateness
& Bull, R
Federal law defines drug shortage as a period of time when the demand or projected demand for the drug in the United States exceeds the supply, 21 USC 356c(h)(2), and FDA considers a shortage resolved when all the manufacturers are able to meet total national historical demand. This is the statutory authority upon which compounded copies of FDA approved GLP-1 drugs have proliferated in the United States creating greater access at a lower cost for patients, albeit with a greater safety risk than the approved, brand named versions
The SURMOUNT-4 trial, which looked at tirzepatide, showed similar trends: Participants lost an average of 20.9% of their body weight over the first 36 weeks (9 months)so, greater and faster weight loss compared to semaglutide
