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Communicate with Your Provider: Keep the healthcare team informed about side effects, especially if they are persistent, severe, or significantly impacting quality of life or ability to stay active and nourished

Both studies were presented during Late-Breaking Clinical Trial sessions

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Ozempic Trulicity pros Effective at lowering A1C in type 2 diabetes Simple, once-weekly injection with pre-set dosing Easy-to-use pen with no need to dial or measure doses Proven cardiovascular benefits in high-risk patients Widely available and often covered by insurance Trulicity cons May result in only moderate weight loss compared to Ozempic Common side effects include nausea, diarrhea, and fatigue Room temperature stability lasts only 14 days May not be as effective for weight management in some patients Ozempic pros Highly effective at lowering A1C and promoting weight loss Once-weekly injection Proven cardiovascular protection Can be stored at room temperature for up to 56 days Popular choice for patients managing both type 2 diabetes and obesity Ozempic cons May cause more intense gastrointestinal side effects (vomiting, nausea) Dose titration required some pens require manual dose setting Slightly more expensive than Trulicity without insurance Risk of gallbladder issues in rare cases 2025 updates and developments Recent studies have shown the benefits of GLP-1 receptor agonists go beyond glycemic control

Saadh MJ, Allela OQB, Ballal S, Mahdi MS, Chahar M, Verma R et al (2025) The effects of microbiota-derived short-chain fatty acids on T lymphocytes: From autoimmune diseases to cancer