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The peptide incorporates two key structural modifications: (i) substitution of alanine with 2-aminoisobutyric acid (Aib) at position 8 , which confers resistance to dipeptidyl peptidase-4 (DPP-4) degradation and extends peptide stability in vivo
This change is often subtle at first
Family-Based and Population-Based Association Studies Validate PTPRD as a Risk Factor for Restless Legs Syndrome. Movement Disorders : Official Journal of the Movement Disorder Society, vol
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